Evidence map›Paper›PMID 41777278›Full record

ArticleInternational journal of dentistry2026

The Association of Periodontitis and Stroke History: Exploring the Role of Hypertension in a Cross-Sectional NHANES Analysis.

Shi-Yin Jin, Qing Liu, Xiao-Qing Cao, Dian-Wei Wu, Yun-Fan Cai, Li-Na Niu, Wen Qin, Tao Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shi-Yin JinState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.
Qing LiuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0000-9123-0538
Xiao-Qing CaoThe Third Affiliated Hospital of Henan Medical University, Xinxiang, 453000, Henan, China.
Dian-Wei WuDepartment of neurology, Air Force Hospital of Eastern Theater Command, Nanjing, Jiangsu, China.
Yun-Fan CaiState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.
Li-Na NiuState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0002-6653-0819
Wen QinState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0000-0003-1639-2531
Tao YeState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China, fmmu.edu.cn.ORCID https://orcid.org/0009-0003-9182-918X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Periodontitis, a chronic inflammatory disease, and stroke, a leading cause of death and disability, share common risk factors and inflammatory pathways. However, the role of key mediators such as hypertension in this relationship remains to be fully elucidated. Methods: This cross-sectional analysis was conducted using data from the NHANES 2009-2014. Participants aged 30 years and older with complete periodontal and stroke data were included ( Results: In unadjusted models, periodontitis was significantly associated with stroke (OR: 5.69; 95% CI: 2.24-20.61). After full adjustment, this association was no longer statistically significant (OR: 1.48; 95% CI: 0.53-5.67). Mediation analysis revealed a significant indirect association of periodontitis on stroke through hypertension (indirect association coefficient = 0.3685, 95% CI: 0.085-0.868), accounting for 31.30% of the total association. The direct association was not significant. Conclusions: Hypertension was identified as a significant mediator in the relationship between periodontitis and stroke. The impact of periodontitis on stroke may operate primarily through its association with blood pressure, highlighting the importance of integrated management of periodontal and cardiovascular health.

Indexed as

cross-sectional analysishypertensioninflammationnational health and nutrition examination survey (NHANES)periodontitisstroke

Identifiers

PMID41777278
PMCPMC12951535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.