Evidence map›Paper›PMID 41777164›Full record

ArticleFuture oncology (London, England)2026

Beamion PANTUMOR-1: rationale and design of a Phase II trial of zongertinib in HER2-overexpressed/amplified or

Alison M Schram, John J Park, Antoine Italiano, Shigehisa Kitano, Ye Guo, Jin Li, Philippe L Bedard, Cedric van Marcke, Ryo Ko, Lukas Lunger and 13 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Future oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Alison M SchramDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6070-2413
John J ParkMacquarie Medical School, Macquarie University, Sydney, NSW, Australia.ORCID 0000-0001-9290-8179
Antoine ItalianoDepartment of Medical Oncology, Institut Bergonié, Bordeaux, France.
Shigehisa KitanoDepartment of Advanced Medical Development, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID 0000-0002-4041-8298
Ye GuoDepartment of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-1813-9815
Jin LiMedical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-0099-874X
Philippe L BedardDivision of Medical Oncology & Hematology, Department of Medicine, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.ORCID 0000-0002-6771-2999
Cedric van MarckeDepartment of Medical Oncology, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Brussels, Belgium.ORCID 0000-0003-3454-0630
Ryo KoDivision of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.ORCID 0000-0002-2551-3529
Lukas LungerGlobal Clinical Development ONCO, Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany.
Daniel M KlotzGlobal Clinical Development ONCO, Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany.
Jo HussainClinical Development Operations, Boehringer Ingelheim Ltd, Bracknell, Berkshire, UK.
Daniela MaierGlobal Biostatistics & Data Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Damijan ErzenGlobal Clinical Development ONCO, Boehringer Ingelheim International GmbH, Biberach an der Riss, Germany.ORCID 0000-0003-1205-4244
David PlanchardDepartment of Medical Oncology, Institut Gustave Roussy, Villejuif, France.ORCID 0000-0002-1565-8310
Hans PrenenMedical Oncology, University Hospital Antwerp, Edegem, Belgium.ORCID 0000-0001-8802-7352
Timothy D ClayMedical Oncology, St John of God Subiaco Hospital, Perth, WA, Australia.ORCID 0000-0002-1953-2694
Joon O ParkDepartment of Medicine, Samsung Medical Center, Seoul, Korea.ORCID 0000-0001-6502-2612
Hyung-Don KimDepartment of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0001-9959-0642
Alberto Hernando-CalvoMedical Oncology, Vall d´Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.ORCID 0000-0002-1692-1125
Yuta MarukiDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-5045-8082
Mariano Ponz-SarviseMedical Oncology, Cancer Center Clinica, Universidad de Navarra, Pamplona, Spain.ORCID 0000-0002-3240-729X
Ecaterina DumbravaInvestigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-1959-0536

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Human epidermal growth factor receptor 2 (HER2, encoded by

Indexed as

Antineoplastic AgentsErb-b2 Receptor Tyrosine KinasesNeoplasmsProtein Kinase InhibitorsAcrylamidesClinical Trials, Phase II as TopicFemaleGene AmplificationHumansImidazolesMutationPyrimidinesTreatment OutcomeAcrylamidesAntineoplastic AgentsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesImidazolesProtein Kinase InhibitorsPyrimidineszongertinibbasket trialBeamion PANTUMOR-1HER2solid tumorsZongertinib

Identifiers

PMID41777164
PMCPMC12977268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.