Evidence map›Paper›PMID 41777124›Full record

ArticleAnnals of medicine2026

Retrorsine impairs liver regeneration by inducing progenitor cell-senescence

Yan Cui, Li Li, Yu He, Shan Shan, Lin Liu, Jiangbo Ren, Hui Wang, Miaoran Yang, Xinyan Zhao, Jidong Jia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan CuiLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Li LiLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yu HeLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Shan ShanLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Lin LiuLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jiangbo RenLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hui WangLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Miaoran YangLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Xinyan ZhaoLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jidong JiaLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Ping WangLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-1395-2014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatic progenitor cells (HPCs) provide an alternative regenerative pathway when hepatocytes are in a senescent state or after chronic liver injury. Yet, their contribution to liver regeneration after partial hepatectomy (PH) remains controversial. The aim of this study is to reveal the regeneration contribution of HPCs after PH when hepatocyte proliferation is totally suppressed.

methodsRetrorsine (RTS) was administered to suppress hepatocyte proliferation in C57BL/6J mice after PH. The regeneration contribution of HPCs was assessed using HPC-specific lineage tracing mice (Sox9

resultsRTS 0-70 mg/kg dose-dependently reduced the PCNA

conclusionWhen hepatocyte proliferation was completely suppressed by RTS, HPCs contributed minimally to liver regeneration owing to cellular senescence, resulting in regeneration failure.

Indexed as

Cellular SenescenceHepatectomyLiver RegenerationPyrrolizidine AlkaloidsReactive Oxygen SpeciesStem CellsAnimalsCell ProliferationHepatocytesLiverMaleMiceMice, Inbred C57BLPyrrolizidine AlkaloidsReactive Oxygen Speciesretrorsinehepatic progenitor cellsPartial hepatectomyretrorsinesenescence

Identifiers

PMID41777124
PMCPMC12961708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.