ArticleJournal of reconstructive microsurgery2026
Regional Nodal Irradiation Impact on Lymphedema, Surgical Outcomes, and Quality-of-Life Following Mastectomy, Axillary Dissection, and Immediate Lymphatic Reconstruction.
Article in Journal of reconstructive microsurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Radiation therapy following axillary lymph node dissection (ALND) is a key risk factor for lymphedema, with regional nodal irradiation (RNI) posing a higher risk. Immediate lymphatic reconstruction (ILR) with microsurgical lymphovenous anastomosis performed concurrently with ALND aims to prevent lymphedema, but its efficacy in the setting of RNI is unclear. This study compares lymphedema incidence, complications, and LYMPH-Q patient-reported outcomes (PROs) after ILR based on receipt of RNI.We retrospectively studied consecutive patients who underwent mastectomy and ALND with ILR between 2017 and 2024 at our institution. Patients receiving radiotherapy were categorized based on receipt of RNI, and outcomes were compared using multivariable regression, adjusting for patient and treatment factors.We identified 119 patients with a mean follow-up time of 25.0 ± 15.5 months, of whom 68.9% (
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