Evidence map›Paper›PMID 41776771›Full record

Trial reportPhysiological reports2026

Oral amino acid tracer delivery detects feeding and exercise changes in myofibrillar protein synthesis rates in male adults.

Michael Mazzulla, Nathan Hodson, Paula J Scaife, Kenneth Smith, Philip J Atherton, Nicholas A Burd, Dinesh A Kumbhare, Daniel R Moore

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael MazzullaFaculty of Kinesiology and Physical Education, Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada.
Nathan HodsonFaculty of Kinesiology and Physical Education, Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada.
Paula J ScaifeMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology, School of Medicine, University of Nottingham, Derby, UK.
Kenneth SmithMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology, School of Medicine, University of Nottingham, Derby, UK.
Philip J AthertonMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, Centre of Metabolism, Ageing and Physiology, School of Medicine, University of Nottingham, Derby, UK.
Nicholas A BurdDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Dinesh A KumbhareDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Daniel R MooreFaculty of Kinesiology and Physical Education, Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5865-4398

Funding

Connaught Fund NR-2015-16Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2023-05382Mitacs (Mitacs Canada) IT15730Ontario Graduate Scholarship
6 · The paper itself

Abstract

The efficacy of oral administration of leucine and phenylalanine tracers to measure MyoPS (LEUMyoPS and PheMyoPS, respectively) in response to varying anabolic stimuli was investigated. Participants were randomized to a rested-fasted (FAST), rested-fed (FED), or exercise-fed (EXFED) condition. FED and EXFED consumed a mixed carbohydrate and AA beverage enriched with L-[1-

Indexed as

Amino AcidsExerciseLeucineMuscle ProteinsMyofibrilsPhenylalanineAdministration, OralAdultFastingHumansMaleMuscle, SkeletalProtein BiosynthesisYoung AdultAmino AcidsLeucineMuscle ProteinsPhenylalanineamino acidsmuscle protein synthesisresistance exercisestable isotopes

Identifiers

PMID41776771
PMCPMC12956835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.