Evidence map›Paper›PMID 41776743›Full record

ArticleThe New phytologist2026

GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean.

Vinavi A Gamage, Mariola Usovsky, Anser Mahmood, Elizabeth De Meyer, Bishnu Dhital, Clinton G Meinhardt, Qijian Song, Lesa J Beamer, Andrew M Scaboo, Melissa G Mitchum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vinavi A GamageDepartment of Plant Pathology and Institute of Plant Breeding, Genetics and Genomics, University of Georgia, Athens, GA, 30602, USA.ORCID https://orcid.org/0009-0002-3640-2709
Mariola UsovskyDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0000-0003-2431-5202
Anser MahmoodDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0009-0004-6731-0473
Elizabeth De MeyerDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0009-0003-0312-6127
Bishnu DhitalDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0009-0002-2247-2220
Clinton G MeinhardtDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0009-0007-4260-9614
Qijian SongSoybean Genomics and Improvement Laboratory, Beltsville Agricultural Research Center, USDA-ARS, Beltsville, MD, 20705, USA.ORCID https://orcid.org/0000-0003-2505-5246
Lesa J BeamerDepartment of Biochemistry, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0000-0001-5689-200X
Andrew M ScabooDivision of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.ORCID https://orcid.org/0000-0002-9670-8446
Melissa G MitchumDepartment of Plant Pathology and Institute of Plant Breeding, Genetics and Genomics, University of Georgia, Athens, GA, 30602, USA.ORCID https://orcid.org/0000-0002-9086-6312

Funding

Division of Integrative Organismal Systems IOS 2152548Missouri Soybean Merchandising Council 16-398-21 through -24Missouri Soybean Merchandising Council 16-400-21 through -24National Institute of Food and Agriculture 2021-67013-35887
6 · The paper itself

Abstract

Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) - NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding. Through the use of a bi-parental mapping population from a cross between the SCN-resistant soybean cultivars Pickett × Peking, a major QTL on chromosome 14 was mapped to a confidence interval containing the GmSNAP14 gene. SCN-resistant genotypes were found to carry one of two variant GmSNAP14 alleles harboring either a deletion or an insertion in GmSNAP14. Expression of full-length transcripts was absent or markedly lower in plants carrying these alleles when compared to susceptible plants. Additionally, the generation of deleted and/or alternatively spliced isoforms coding for GmSNAP14 C-terminal variant proteins was pronounced in resistant plants, suggesting that SCN resistance may result from a combination of diminished GmSNAP14 expression and GmSNAP14 protein variants. CRISPR/Cas9-mediated knockout of GmSNAP14 enhanced resistance to SCN, consistent with susceptibility gene behavior indicating GmSNAP14 as a potential nematode virulence target. Our findings can be leveraged through the use of genome editing and conventional breeding techniques utilizing native alleles to develop resistant soybean cultivars.

Indexed as

Disease ResistanceGlycine maxPlant DiseasesPlant ProteinsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsTylenchoideaAllelesAlternative SplicingAnimalsGene Expression Regulation, PlantGenes, PlantProtein IsoformsQuantitative Trait LociPlant ProteinsProtein IsoformsSoluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinseffectorHeteroderaresistancesoybean cyst nematodevesicular traffickingα‐SNAP

Identifiers

PMID41776743
PMCPMC13103430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.