SynthesisJournal of orthopaedic surgery and research2026
Analgesic effects of different administration routes of non-steroidal anti-inflammatory drugs in orthopedic postoperative pain management: a meta-analysis based on randomized controlled trials.
Synthesis in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo explore the differences in the efficacy and safety of different administration routes (oral, intravenous, intramuscular) of non-steroidal anti-inflammatory drugs (NSAIDs) in orthopedic postoperative pain management.
methodsRandomized controlled trials were systematically retrieved from PubMed, Medline, Web of Science, Cochrane Library, and EMBASE databases. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool (RoB tool), and meta-analysis was performed using RevMan 5.3 software. The experimental group received NSAIDs via oral, intravenous, or intramuscular routes, while controls received neither NSAIDs nor other analgesics. The primary outcome measures included analgesic drug usage and the occurrence of adverse reactions.
results5 studies were included, involving 7971 patients, with 3340 cases in the oral group, 107 cases in the intravenous group, and 982 cases in the intramuscular group. There was no significant difference in the risk of adverse reactions among different administration routes of NSAIDs in orthopedic postoperative patients (RD = 0.00, 95% CI [-0.01-0.02], P = 0.66). The use of analgesic drugs in the treatment group (NSAIDs groups with different administration routes) was significantly less than that in the control group (OR = 0.34, 95% CI [0.23-0.52], P < 0.001).
conclusionIntravenous administration provides significant short-term analgesic effects, oral administration offers stable long-term pain relief. While there is no significant difference in the overall risk of adverse reactions among different administration routes, route-specific reactions exist. Clinicians should select the appropriate administration route based on individual patient conditions.
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