ArticleMalaria journal2026
A maximal-coverage approach to prioritizing newborn sickle cell screening sites in Uganda using a sickle cell-malaria co-risk surface.
Article in Malaria journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUganda has a high, spatially heterogeneous burden of sickle cell disease (SCD) with national screening indicating sickle cell trait at 13.1 percent and disease at 0.7 percent, concentrated in the northern and eastern regions where Plasmodium falciparum transmission remains intense. Newborn sickle cell screening and follow up care programmes need a robust method to prioritize the selection of screening hubs that aligns sickle cell genetic risk and malaria transmission intensity with travel-time access to health facilities where newborn screening and early sickle cell anaemia (SCA) care can be delivered.
methodsSickle haemoglobin (HbS) allele frequency was interpolated from two independent district-level surveys with Empirical Bayesian Kriging (EBK). Malaria endemicity was summarised as the 2015-2024 mean Plasmodium falciparum parasite prevalence in children aged 2-10 years (PfPR
resultsNational HbS allele frequency had a median of 6.5 percent (IQR 4.8-8.5), and 72.2 percent of pixels exceeded 5.0 percent. The area-weighted mean PfPR
conclusionsUsing a HbS-PfPR
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