SynthesisJournal of ovarian research2026
Gut microbiota, a new approach to management of polycystic ovary syndrome: a systematic review, meta-analysis and meta-evidence of 26 randomized controlled trials.
Synthesis in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Trial
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Exploring emerging concepts in the pathophysiology of PCOS: microbiome dysbiosis and immunological dysregulation.Reproduction & fertility · 2026Review
- Gut microbiota in PCOS: key microbial changes, potential mechanisms and clinical applications.Journal of translational medicine · 2026Review
- Gut microbiota and polyendocrine metabolic ovarian syndrome: an integrated gut-metabolism-endocrine-ovary axis.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Ketogenic diet combined with probiotics for polyendocrine metabolic ovarian syndrome: research progress from the perspective of the gut microbiota-host metabolic axis.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence regarding the beneficial effects of biotics supplementation in polycystic ovary syndrome (PCOS) remains inconsistent. To address this discrepancy, this study aimed to investigate the impact of biotics on health outcomes in women with PCOS by conducting a systematic review and meta-analysis.
methodsWeb of Science ISI, Scopus, PubMed, Cochrane, and Embase databases were comprehensively searched up to October 2025 to identify RCTs on prebiotics, probiotics and synbiotics on health outcomes.
resultsTwenty-six RCTs with participants aged 25 to 29 were included in the current meta-analysis. All participants were followed up for 8 weeks to 24 weeks. Results showed that prebiotics or probiotics and synbiotics are effective in reducing weight (SMD: -0.57, 95% CI: -1.05, -0.08) and body mass index (BMI) (SMD: -0.42, 95% CI: -0.75, -0.09), waist circumference (WC) (SMD: -0.78, 95% CI: -1.28, -0.28), insulin (SMD: -0.60, 95%CI: -1.12, -0.08), HOMA-IR (SMD: -0.79, 95%CI: -1.48, -0.11), malondialdehyde (MDA) (SMD: -0.77, 95% CI: -1.17, -0.37), and triglyceride (TG) (SMD: -0.62, 95% CI: -1.08, -0.16), low-density lipoprotein-cholesterol (LDL-C) (SMD:-0.71, 95%CI: -1.21, -0.20), and total testosterone (SMD: -1.47, 95% CI: -2.32, -0.62), and led to a significant increase for total antioxidant capacity (TAC) (SMD: 0.58, 95% CI: 0.14, 1.01), and high-density lipoprotein-cholesterol (HDL-C) (SMD: 0.38, 95% CI: 0.15, 0.61).
conclusionsThis meta-analysis suggests that prebiotic, probiotic, or synbiotic supplementation may have beneficial effects on several health outcomes in women with PCOS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.