Evidence map›Paper›PMID 41776371›Full record

ReviewNature cell biology2026

Amniogenesis in embryos and stem cell models.

Timothy Theodore Ka Ki Tam, Shao Xu, Yunfan Li, Xiao Wang, Yicong Chen, Jilong Guo, Zhen Feng, Guocheng Lan, Degong Ruan, Dong Han and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Timothy Theodore Ka Ki TamInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China. tim.tam@hkstemcell.hk.
Shao XuInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Yunfan LiInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Xiao WangInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Yicong ChenSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jilong GuoInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Zhen FengInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Guocheng LanInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Degong RuanInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Dong HanInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-8619-1543
Qingqing ZhangInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Liyang MaInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Fang LiuInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China.
Guojun ShengInternational Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan. sheng@kumamoto-u.ac.jp.ORCID http://orcid.org/0000-0001-6759-3785
Pentao LiuInnoHK Centre for Translational Stem Cell Biology, Hong Kong Science Park, Hong Kong SAR, China. pliu88@hku.hk.ORCID http://orcid.org/0000-0001-5774-9678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The amnion is a transient extra-embryonic tissue whose formation, known as amniogenesis, is vital to amniote embryogenesis. The growing body of knowledge on amniotic lineage emergence and functions has enabled a more comprehensive understanding of the underlying molecular mechanisms and thus may inspire future improvement in stem cell-based amniogenic models. In this Review we first introduce cavitation amniogenesis as a hallmark of human peri-implantation embryogenesis before addressing how cavitation amniogenesis is similar in humans and non-human primates but contrasts with folding amniogenesis in other amniotes such as mice and pigs. We also highlight the ongoing debate of whether primate amniogenesis harbours lineage plasticity for specifying germ cell fate and further discuss the two-wave amniogenesis model and its basis on the pluripotency transition. Finally, we summarize the potential of the recent stem cell-based human embryo models in elucidating amniotic formation and functions.

Indexed as

AmnionEmbryo, MammalianEmbryonic DevelopmentEmbryonic Stem CellsStem CellsAnimalsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalHumansModels, Biological

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.