Evidence map›Paper›PMID 41776365›Full record

ArticlePediatric research2026

Neurodevelopmental outcomes of infants born at high altitude: evidence from Tibet.

Yang Zhou, Xinqin Liu, Qian Zhang, Ming Li, Siyao Zeng, Qian Dong, Shanshan Meng, Xiaoru Dong, Qunpei Zhaxi, Duoji Luosang and 5 more

Abstract read
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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yang Zhou *Department of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Xinqin Liu *Department of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Qian Zhang *Department of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Ming LiDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Siyao ZengDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Qian DongDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Shanshan MengDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Xiaoru DongDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China.
Qunpei ZhaxiDepartment of Child Health, Fokind Hospital for Women & Children, Lhasa, China.
Duoji LuosangDepartment of Child Health, Fokind Hospital for Women & Children, Lhasa, China.
Luobu OuzhuDepartment of Child Health, Fokind Hospital for Women & Children, Lhasa, China.
Xueting GaoDepartment of Child Health, Northwest Women's and Children's Hospital, Xi'an, China.
Wenbin ZhangDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China. zhangwenbin1978@126.com.
Kejun DuDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China. dukejun@fmmu.edu.cn.
Xiaoming ChenDepartment of Occupational and Environmental Health, Shanxi Key Laboratory of Environment Health Hazard Assessment and Protection, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, The Fourth Military Medical University, Xi'an, China. xiaomingchen@fmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn contrast to the extensive research on the effects of high-altitude exposure on adult neurological function, fetal and pediatric neurodevelopment in high-altitude environments has received relatively little attention. This study aimed to determine whether exposure to high-altitude exposure during gestation and infancy could influence neurodevelopmental outcomes compared with low-altitude infants.

methodsA total of 50 high-altitude-born and 100 low-altitude-born infants were studied. Parents were followed longitudinally and instructed to complete the Ages and Stages Questionnaire, 3rd edition (ASQ-3), when their infants reached 6, 12, and 18 months of age. The primary outcome measures included neurodevelopmental scores and the proportion of infants classified as failing in the five ASQ-3 domains.

resultsHigh-altitude infants had lower gross motor scores and higher failure rates. Subgroup analysis revealed no significant differences attributable to confounding factors. Regression analysis identified high-altitude exposure as the only significant predictor of gross motor delay.

conclusionsPrenatal and postnatal exposure to high-altitude exposure was found to be associated with an increased risk of gross motor neurodevelopmental delay in infants. IMPACT: This is the first prospective cohort study to compare the neurodevelopmental outcomes of high-altitude born/raised infants with those of low-altitude controls. Infants born and raised at high-altitude exhibited lower neurodevelopmental scores and a higher likelihood of failing in the gross motor domain of ASQ-3. High-altitude exposure had no negative influence on infants' physical growth and other neurodevelopmental domains assessed by the ASQ-3.

Identifiers

PMID41776365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.