ArticleCancer medicine2026
Characteristics and Prognosis of Early-Onset vs. Late-Onset Colon Cancer: A Propensity Score Matching Analysis Based on Histology.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
objectivesThe prognostic value of age at diagnosis in colon cancer is poorly understood. This study evaluated the influence of age at diagnosis and histologic subtype on colon cancer prognosis using data from 180,804 patients in the SEER database.
methodsPatients were stratified into early-onset and late-onset groups and by histology-adenocarcinoma or mucinous adenocarcinoma. Early-onset colon cancer was associated with more advanced tumor stages. Propensity score matching balanced cohorts for Kaplan-Meier and Cox regression analyses of cancer-specific survival (CSS) and surgery-specific survival (SSS).
resultsSurvival analyses revealed that patients with early-onset adenocarcinoma had the most favorable CSS and SSS, whereas those with late-onset mucinous adenocarcinoma experienced the worst outcomes; no significant age-related differences emerged histology-stratified. Importantly, among nonmetastatic patients, early-onset adenocarcinoma showed significantly poorer SSS compared to late-onset adenocarcinoma.
conclusionThese findings emphasize the necessity of integrating age and histologic type for accurate prognostic assessment and personalized treatment strategies in colon cancer.
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