Evidence map›Paper›PMID 41776352›Full record

ReviewNPJ cardiovascular health2025

Breaking binary in cardiovascular disease risk prediction.

Yichi Zhang, Akl C Fahed

Abstract readReview
In one paragraph

Review in NPJ cardiovascular health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yichi ZhangDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Akl C FahedCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. afahed@mgh.harvard.edu.

Funding

Coronary plaque changes with statin and colchicine among people with high polygenic risk- a mechanistic pilot studyR01HL164629 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Akl C Fahed, Michael TseYin Lu · 2023 to 2026
$3.3M
Integrating genomic and nongenomic risk for coronary artery diseaseK08HL161448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Akl C Fahed · 2022 to 2026
$751k
NHLBI NIH HHS K08 HL161448NHLBI NIH HHS K08HL161448NHLBI NIH HHS R01 HL164629
6 · The paper itself

Abstract

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the world. However, advances in genetics, omics research, machine learning (ML), and precision medicine have inspired revolutionary new tools in ASCVD risk stratification. Together, polygenic risk scores (PRS) and composite ML-based algorithms help shift the paradigm away from binary predictions towards more comprehensive continuum models. Continued efforts are needed to address socioeconomic and racial disparities in the PRS space.

Identifiers

PMID41776352
PMCPMC12810761

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.