Evidence map›Paper›PMID 41776322›Full record

ReviewNpj imaging2026

Smart microscopy: adaptive microscope control to improve the way we see life.

Alfredo Rates, Josiah B Passmore, Nils Norlin, Lukas C Kapitein

Abstract readReview
In one paragraph

Review in Npj imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A custom two-in-one HIST and line-scanning confocal excitation module.bioRxiv : the preprint server for biology · 2026
    Article
  2. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alfredo RatesCell Biology, Neurobiology and Biophysics, Department of Biology, Utrecht University, Utrecht, The Netherlands.
Josiah B PassmoreCell Biology, Neurobiology and Biophysics, Department of Biology, Utrecht University, Utrecht, The Netherlands.
Nils NorlinDepartment of Experimental Medical Science, Lund University Bioimaging Centre (LBIC) & NanoLund, Lund University, Lund, Sweden.
Lukas C KapiteinCell Biology, Neurobiology and Biophysics, Department of Biology, Utrecht University, Utrecht, The Netherlands. l.kapitein@uu.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smart microscopy lies at the intersection of biology, optics, engineering, and computer science. Unlike traditional microscopes, smart systems actively adapt their acquisition settings in real time based on information extracted from the sample, allowing experiments to navigate competing demands such as resolution, speed and sample health. In this review, we present a practical framework for what makes a microscope "smart," defining smart microscopy as the combination of real-time analysis, feedback control, and automated actuation. To guide implementation, we classify smart microscopy approaches by experimental goal (quality-, event-, target-, information- or outcome-driven) and discuss the corresponding strategies for analysis and control. Finally, we highlight key challenges and the growing role of community-driven efforts in making smart microscopy more accessible and widely adopted across the life sciences.

Identifiers

PMID41776322
PMCPMC12957318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.