Evidence map›Paper›PMID 41776304›Full record

SynthesisClinical oral implants research2026

Tobacco Smoking and Smoke-Free Products as Risk Factors for Dental Implants: A Systematic Review.

Calciolari Elena, Corbella Stefano, Dourou Marina, Ercal Pinar, Donos Nikolaos

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Clinical oral implants research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Calciolari ElenaCentre for Oral Clinical Research, Institute of Dentistry, Faculty and Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0001-8781-1997
Corbella StefanoDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milano, Italy.
Dourou MarinaCentre for Oral Clinical Research, Institute of Dentistry, Faculty and Medicine and Dentistry, Queen Mary University of London, London, UK.
Ercal PinarCentre for Oral Clinical Research, Institute of Dentistry, Faculty and Medicine and Dentistry, Queen Mary University of London, London, UK.
Donos NikolaosCentre for Oral Clinical Research, Institute of Dentistry, Faculty and Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4117-9073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis systematic review aimed to investigate the effect of tobacco smoking and smoke-free products as risk factors for dental implants. MATERIALS AND

methodsThree databases were searched to identify studies reporting on the risk of implant failure/survival in tobacco smokers or smoke-free users as compared to non-smokers in studies with ≥ 1 year of follow-up post-implant loading. Data on biological complications and radiographic peri-implant crestal bone loss (CBL) were also collected. Meta-analyses computed the Odds Ratio (OR) of implant survival with its confidence interval by applying the DerSimonian and Laird's random effect method, with p set at < 0.01.

resultsForty-five articles reporting on 44 studies were included, 41 of which reported on the effect of cigarette smoking, with a follow-up from 1 to up to 17 years. Overall, a significantly reduced implant survival both at implant and patient level was indicated in cigarette smokers (OR = 0.40, 95% CI 0.27; 0.61, p < 0.001 and OR = 0.43, 95% CI 0.20; 0.90, p = 0.02, respectively). An increased CBL of 0.64 mm (95% CI 0.29; 0.99, p < 0.001) was also suggested in cigarette smokers, and the majority of studies reported a higher incidence of peri-implantitis. Insufficient data are available for smoke-free users.

conclusionsAlthough tobacco smoking is not considered an absolute contraindication for implant therapy, evidence indicates that it has a detrimental effect on peri-implant tissues, leading to an increased risk of implant failure and crestal bone loss. Individual behavioural counselling for smoking cessation should always be integrated in the treatment plan of patients receiving implant-supported rehabilitations.

trial registrationPROSPERO number: CRD42024628116.

Indexed as

Dental ImplantsDental Restoration FailureTobacco SmokingAlveolar Bone LossHumansRisk FactorsDental Implantsdental implantselectronic cigarettesrisk factorssmokingtobacco usevaping

Identifiers

PMID41776304
PMCPMC12975700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.