ArticleScientific reports2026
Brain connectivity and its relation to cognitive function in patients with post-COVID 19 condition after mild infection.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06042530 (Cognitive Impairment and Fatigue After Mild to Moderate COVID-19 - Relation to Biomarkers and Neuronal Network Functions), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Cognitive Impairment and Fatigue After Mild to Moderate COVID-19 - Relation to Biomarkers and Neuronal Network Functions
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological symptoms are common in post-COVID-19 condition (PCC) and have been linked to underlying brain alterations. However, in individuals with PCC following a mild infection without hospitalization, such alterations are rarely detected using conventional neuroimaging techniques. This study aims to investigate brain connectivity in patients with PCC with cognitive symptoms after mild COVID-19 infection, using resting-state functional magnetic resonance imaging (rs-fMRI). Additional aims were to explore associations between brain connectivity, neuropsychological performance, and self-reported fatigue and emotional status. Patients with PCC (n = 22) and lasting cognitive symptoms and fatigue were consecutively recruited from a regional rehabilitation unit and compared with a convenience sample of non-symptomatic controls (n = 19). The assessments were conducted on average 32 months post-infection and included 3 Tesla rs-fMRI, neuropsychological testing, and self-report measures of fatigue (MFI-20), anxiety, and depression (HADS). Patients with PCC had elevated functional connectivity in brain regions associated with the default mode network (DMN) compared to controls. No significant correlations were found between functional connectivity, neuropsychological test performance, fatigue, anxiety, or depression. Our findings suggest persistent alterations in DMN connectivity in PCC with cognitive symptoms and fatigue, underscoring the need for continued larger studies on brain functioning in this patient group.Clinical trial registration: No. NCT06042530.
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