Evidence map›Paper›PMID 41776202›Full record

ArticleScientific reports2026

Camel milk extracellular vesicles as a promising antibiotic alternative: gastrointestinal stability, antimicrobial, and immunoregulatory activities.

Jiaotong Fu, Longxia Fu, Bintao Zhai, Huiyu Shi, Hui Yang

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiaotong FuCollege of Medical, Qinghai University, Xining, 810016, China.
Longxia FuChina Animal Agriculture Association, China Camel Industry Association, Beijing, 100044, China.
Bintao ZhaiLanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Huiyu ShiSchool of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, China.
Hui YangCollege of Medical, Qinghai University, Xining, 810016, China. yanghui@qhu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing demand for sustainable alternatives to in-feed antibiotics in animal production underscores the scarcity of thorough research on natural bioactive carriers that endure gastrointestinal digestion and offer multiple benefits. This study explored the potential of camel milk extracellular vesicles (CM-EVs) as natural alternatives to antibiotics in animal production. The research evaluated the gastrointestinal stability and multifunctional properties of CM-EVs through in vitro analysis. Simulated digestion experiments revealed that CM-EVs maintained their structural integrity throughout the gastrointestinal tract. Furthermore, they exhibited significant dose-dependent antioxidant activity and demonstrated effective antimicrobial properties against Escherichia coli and Staphylococcus epidermidis. In macrophage models, CM-EVs enhanced cell viability and selectively reduced the release of IL-1β and IL-6, without affecting TNF-α levels. These results indicate that CM-EVs are stable during digestion and possess antioxidant, antimicrobial, and immunomodulatory properties, highlighting their potential as a natural supplement to enhance animal health and reduce reliance on conventional antibiotics.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsExtracellular VesiclesGastrointestinal TractMilkAnimalsAntioxidantsCamelusEscherichia coliMacrophagesMiceStaphylococcus epidermidisAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsAntimicrobialAntioxidantCamel milkExtracellular vesiclesImmunomodulationVeterinary feed additive

Identifiers

PMID41776202
PMCPMC12988212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.