Evidence map›Paper›PMID 41776113›Full record

ReviewCell and tissue research2026

Proteolytic dysregulation in the skin: insight from rare monogenic skin diseases.

Zhongtao Li, Sheng Wang, Diana C Blaydon, David P Kelsell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhongtao LiDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Sheng WangDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Diana C BlaydonCentre for Cell Biology and Cutaneous Research, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, Whitechapel, London, E1 2AT, UK.
David P KelsellCentre for Cell Biology and Cutaneous Research, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, Whitechapel, London, E1 2AT, UK. d.p.kelsell@qmul.ac.uk.

Funding

Medical Research Council MR/L010402/1 and MR/S009914/1Qimingxing Research Fund for Young Talents HXQMX0045
6 · The paper itself

Abstract

Proteases are essential enzymes that, through the breakdown of proteins, regulate many aspects of tissue homeostasis including barrier function, cellular signaling, and tissue repair mechanisms in organisms. Disease gene discovery in a number of monogenic skin diseases has deepened the knowledge of how proteases and protease inhibitors can regulate skin homeostasis, keratinocyte desmosome-mediated cell adhesion, and epidermal barrier function. This short review details the association of protease dysregulation with monogenic skin diseases, postulated disease mechanisms, and emerging therapeutic strategies.

Indexed as

Peptide HydrolasesProteolysisSkinSkin DiseasesAnimalsHumansPeptide HydrolasesCathepsinDesquamationKeratinocyteSerpinSkin barrier

Identifiers

PMID41776113
PMCPMC12956936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.