ArticleAAPS PharmSciTech2026
Developing and Evaluating Stable Microemulsion Systems for Potential Intranasal and Transdermal Application of Omeprazole.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Omeprazole is the first in a class medication that inhibits gastric secretion. However, it has a low stability, low bioavailability, and a short half-life after peroral administration. In the current study, nonionic microemulsions containing omeprazole were formulated and characterized for transdermal and intranasal administration as alternative application routes. The droplet size, rheological characteristics, polydispersity index, permeability through rat and human skin, rat epidermis, and in vivo bioavailability in rats were studied. With these formulations with droplet sizes below 100 nm, an omeprazole permeation with fluxes ranging from 0.86 to 9.945 µg·cm
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Registered trials
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