Evidence map›Paper›PMID 41776040›Full record

ArticleNPJ cardiovascular health2025

AI approaches for predicting progression to acute coronary syndrome among stable coronary heart disease patients.

Haozhong Ma, Hexiang Bai, Jiahuan Yan, Qiyuan Chen, Zihan Ma, Shuo Tong, Yuxuan Zhan, Ruijia Wu, Hongxia Xu, Jian Wu

Abstract read
In one paragraph

Article in NPJ cardiovascular health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haozhong MaState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hexiang BaiState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Jiahuan YanZhejiang Key Laboratory of Medical Imaging Artificial Intelligence, Hangzhou, China.
Qiyuan ChenZhejiang Key Laboratory of Medical Imaging Artificial Intelligence, Hangzhou, China.
Zihan MaState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Shuo TongState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yuxuan ZhanState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ruijia WuAntai College of Economics and Management, Shanghai Jiao Tong University, Shanghai, China. rjwu@sjtu.edu.cn.
Hongxia XuLiangzhu Laboratory and WeDoctor Cloud, Hangzhou, China. Einstein@zju.edu.cn.ORCID http://orcid.org/0000-0001-5384-4627
Jian WuState Key Laboratory of Transvascular Implantation Devices and the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Wujian2000@zju.edu.cn.

Funding

Key Research and Development Program of Zhejiang Province 2023C03053Key Research and Development Program of Zhejiang Province 2024SSYS0026National Key Research and Development Program of China 2024YFA1015600National Natural Science Foundation of China 82202984Natural Science Foundation of China 12301382
6 · The paper itself

Abstract

Coronary heart disease (CHD), including its acute manifestation, acute coronary syndrome (ACS), remains a leading cause of morbidity and mortality worldwide. Early identification of ACS is critical for reducing the global burden of CHD, yet traditional diagnostic methods are often invasive, costly, and time consuming. In this study, we introduce an AI-driven approach that utilizes electronic health records (EHR) to identify transitions from stable CHD to ACS, using a comprehensive dataset of 12,336 patient records from 131 medical institutions in Jiangsu Province, China. The proposed model, applying the T2G-Former to predict ACS in 12 months, demonstrated superior performance, with an area under the curve of 0.953 and a sensitivity of 0.814 on the test set. Model interpretability was supported by SHAP values, which clarified the contribution of individual clinical variables. Our findings highlight the potential of AI-enabled EHR analysis for scalable early ACS detection and clinical decision support.

Identifiers

PMID41776040
PMCPMC12912388

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.