Evidence map›Paper›PMID 41775979›Full record

ArticleTechniques in coloproctology2026

Quality of life before and after redo IPAA: does pouch salvage improve quality of life?

S D Holubar, A Alipouriani, O Lavryk, J Lipman, A E Kanters, B Cohen, K Falloon, F Rieder, T Qazi, E Gorgun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Techniques in coloproctology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

S D HolubarDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA. holubas@ccf.org.
A AlipourianiDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
O LavrykDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
J LipmanDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
A E KantersDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
B CohenDepartment of Gastroenterology & Hepatology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, USA.
K FalloonDepartment of Gastroenterology & Hepatology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, USA.
F RiederDepartment of Gastroenterology & Hepatology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, USA.
T QaziDepartment of Gastroenterology & Hepatology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, USA.
E GorgunDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
S R SteeleDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.
D LiskaDepartment of Colon & Rectal Surgery, Digestive Diseases Institute, Cleveland Clinic, 9500 Euclid Ave. A30, Cleveland, OH, 44195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuality of life (QoL) and functional outcomes after redo ileoanal pouch (IPAA) surgery are worse than after primary (index) pouch surgery. However, QoL in failing pouches compared to after redo IPAA has not been reported. We hypothesized that QoL after redo IPAA would be improved compared with failing IPAAs immediately prior to redo surgery.

methodsAdults who underwent redo IPAA (1984-2024), had successful loop ileostomy closure, and at least one pouch survey were included. Our primary outcome was the Cleveland Global Quality of Life Index (CGQLI; range, 0 [lowest] to 1 [highest]). Survey responses before and after redo IPAA were compared using unmatched and matched pair analyses.

resultsA total of 528 redo pouches were included: pouch excision with neo-IPAA in 318 (60%) and pouch repair with neo-IPAA in 210 (40%); 298 (56%) had follow-up survey data available. After redo IPAA, social, work, and sexual restrictions all decreased (p ≤ 0.05), and bowel movements decreased from 10 to 8 per 24 h (p = 0.05), whereas urgency, incontinence, seepage, pad usage, fiber, antidiarrheal usage, and dietary restrictions were comparable to before redo IPAA. After redo IPAA, quality of health, quality of energy, QoL, and CGQLI were significantly higher than those before redo IPAA (p < 0.0001). When surveyed after redo IPAA, 86% of patients would undergo redo surgery again, 88% would recommend redo IPAA, and happiness with surgery increased (p = 0.001).

conclusionRedo IPAA improved quality of life and restrictions observed prior to redo pouch surgery without compromising functional outcomes for most patients.

Indexed as

Colonic PouchesProctocolectomy, RestorativeQuality of LifeReoperationSalvage TherapyAdultFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesSurveys and QuestionnairesTreatment OutcomeCrohn’s diseaseIleoanal pouchInflammatory bowel diseasePouch salvageQuality of lifeSurgeryUlcerative colitis

Identifiers

PMID41775979
PMCPMC12966209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.