ReviewNpj biological timing and sleep2025
Circadian regulation of extracellular vesicle biogenesis, composition, and release.
Review in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exerkine-loaded exosomes in muscle aging: a nexus of exercise, regeneration, and crosstalk.Frontiers in cell and developmental biology · 2026Review
- Extracellular RNAs as Messengers and Early Biomarkers in Neurodegeneration.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms in mammals are governed by cell-autonomous oscillators that synchronize physiological functions through central and peripheral communication. Extracellular vesicles (EVs) mediate intercellular and systemic signaling, with time-of-day-dependent release and cargo composition regulated by the circadian clock. This regulation involves both transcriptional and post-transcriptional mechanisms affecting genes involved in EV biogenesis. Studies in diverse models show EVs impact physiological and pathological processes, including inflammation, cardiovascular disease, chronic kidney disease, and cancer. EVs also serve as important biomarkers, especially in cancer. The accompanying article explores how clock proteins regulate multiple aspects of EV biology and highlights the significance of circadian dysregulation in EV-associated pathologies. Understanding EV-mediated signaling within the framework of circadian rhythms is critical for improving disease diagnosis, informing treatment strategies, developing therapeutic applications, and enhancing the diagnostic utility of EVs. This insight may pave the way for novel chronotherapy approaches in clinical practice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.