ArticleCommunications biology2026
G-protein activation of the dark-state conformation of the visual G protein-coupled receptor rhodopsin by releasing critical structural constraints.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
G protein-coupled receptors (GPCRs) operate through the binding and activation of heterotrimeric G proteins. Ligand interaction drives the receptor's transition from an inactive to an active state, ultimately triggering G-protein activation and downstream signal transduction. The visual GPCR rhodopsin contains the chromophore 11-cis-retinal, which is covalently bound and functions as an inverse agonist, maintaining very low basal activity in the absence of light. Disruption of this basal receptor activity can lead to physiological consequences associated with retinal diseases such as congenital stationary night blindness and retinitis pigmentosa. Here, we describe a functional dark-state rhodopsin generated through engineered double and triple mutations at three well-defined structural microswitches that regulate the conformational stability of the dark ground-state: i) T94
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