Evidence map›Paper›PMID 41775956›Full record

ArticleGeroScience2026

Association of physical activity with incident dementia and cognitive decline among Australian older adults.

Yang Chen, Danijela Gasevic, Alice Owen, Shivangi Shah, Dragan Ilic, Joanne Ryan, Robyn L Woods, Stella Talic, Rory Wolfe, Suzanne G Orchard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang ChenSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Danijela GasevicSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Alice OwenSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Shivangi ShahSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Dragan IlicSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Stella TalicSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia. Suzanne.Orchard@monash.edu.ORCID http://orcid.org/0000-0003-0211-3183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the association between physical activity (PA) intensity and dementia and cognitive decline in Australian community-dwelling older adults. This prospective cohort study uses data from 11,655 older adults (mean age (standard deviation, SD) = 75.0 (4.2) years, 53.4% females, 52.9% had completed ≥ 12 years of education), who were participants in the ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial and its observational follow-on (ASPREE-XT) and the ASPREE Longitudinal Study of Older Persons (ALSOP) sub-study. Participants self-reported the exposure of usual PA intensity (never/rarely, light, moderate, vigorous). Dementia was adjudicated using the Diagnostic Manual of Mental Disorders 4th Edition and supporting evidence; cognitive decline was defined as a > 1.5 standard deviation reduction from baseline on any cognitive assessment. Associations were explored using hazard ratios from Cox regression models with adjustment for demographic, socio-economic, behavioural and clinical factors. Of 11,655 participants (mean age 75.0 years) over a median 10.4-year follow-up, 931 (8.0%) developed dementia and 3552 (30.8%) cognitive decline. Compared with light PA, dementia or cognitive decline risk was 79% (95% CI 1.14-2.83) and 58% (95% CI 1.21-2.05) higher, respectively, among those who rarely/never engaged in PA, but no further decreases occurred with higher levels of PA. Engagement in light PA may help lower dementia and cognitive decline risk in older adults.

Indexed as

Cognitive DysfunctionDementiaExerciseAgedAged, 80 and overAustraliaFemaleHumansIncidenceIndependent LivingLongitudinal StudiesMaleProspective StudiesRisk FactorsAgeingCognitive declineDementiaGerontologyOlder adultsPhysical activity

Identifiers

PMID41775956
PMCPMC13356129

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.