Evidence map›Paper›PMID 41775941›Full record

ArticleNpj biological timing and sleep2025

Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.

Rafael Lazar, Fatemeh Fazlali, Marine Dourte, Christian Epple, Oliver Stefani, Manuel Spitschan, Christian Cajochen

Abstract read
In one paragraph

Article in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Neurobiophilia.Brain sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rafael LazarCentre for Chronobiology, Psychiatric University Clinics (UPK) Basel, Basel, Switzerland.
Fatemeh FazlaliCentre for Chronobiology, Psychiatric University Clinics (UPK) Basel, Basel, Switzerland.
Marine DourteSleep and Chronobiology Laboratory, GIGA-CRC Human Imaging Unit, University of Liège, Liège, Belgium.
Christian EppleCentre for Chronobiology, Psychiatric University Clinics (UPK) Basel, Basel, Switzerland.
Oliver StefaniLucerne University of Applied Sciences and Arts, Horw, Switzerland.
Manuel SpitschanTranslational Sensory & Circadian Neuroscience, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Christian CajochenCentre for Chronobiology, Psychiatric University Clinics (UPK) Basel, Basel, Switzerland. christian.cajochen@upk.ch.

Funding

European Training Network LIGHTCAP under the Marie Skłodowska-Curie actions framework H2020-MSCA-ITN-2019 860613
6 · The paper itself

Abstract

Whether light exposure during the day reduces non-visual light effects later in the evening has not been studied in adolescents. We investigate whether afternoon-early evening (AEE) light interventions (130 lx, 2500 lx, 4.5 h, compared to 6.5 lx illuminance) would increase melatonin levels during later evening light exposure (130 lx) in a counterbalanced crossover study with 22 adolescents (14-17 years, 11 female). Contrary to our hypothesis, evening melatonin levels decreased after AEE bright light exposure, while sleepiness and vigilance were unaffected, and skin temperature showed no clear changes. The AEE light had acute alerting effects and bright light exposure in the 32 h before laboratory entry was associated with higher evening melatonin and sleepiness. These findings suggest that bright AEE light increases alertness but may delay melatonin production by interfering with circadian rhythms. The study highlights the complex effects of light timing and its implications for managing adolescents' light exposure.

Identifiers

PMID41775941
PMCPMC12912342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.