ReviewNpj biological timing and sleep2025
Endocrine regulation of circadian rhythms.
Review in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review.Function (Oxford, England) · 2026Pooled it
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Metabolic Dyshomeostasis, neuroinflammation, and glymphatic clearance deficits as convergent drivers of Alzheimer's disease: an exposome-based conceptual framework for prevention.Metabolic brain disease · 2026Review
- Beyond canonical homeostasis: Dynamic, plastic, and intermittently unregulated physiology as the norm.Physiological reports · 2026Review
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocrine journal · 2026Review
- The interplay between chronobiology, neuroinflammation, and the glymphatic system in neurodegenerative diseases.Molecular biology reports · 2026Review
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sleep quality, insomnia, chronic fatigue, and work performance in three-shift and fixed-night-shift nurses: a comparative cross-sectional study.Journal of Korean biological nursing science · 2026Article
- The Inflammaging-Redox-InflammamiR Axis in Metabolic Aging: From Diagnostic Clusters to Integrated Risk Phenotypes.Biomolecules · 2026Review
- Exposure timing is a determinant of fine particulate matter (PM2.5) pulmonary, vascular, and metabolic toxicity in male mice.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Temporal Vulnerability of the Blood-Brain Interface in Stroke: Molecular Mechanisms of Circadian Dynamics, Inflammation, and Aging.International journal of molecular sciences · 2026Review
- D-Box Binding Protein (DBP) as a Circadian Output Regulator: Molecular Mechanisms, Tissue-Specific Functions, and Disease Relevance.International journal of molecular sciences · 2026Review
- Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype.Sleep · 2026Article
- Chronotype score is associated with testosterone levels and estradiol-to-testosterone ratio in young adult Saudi women: a cross-sectional study.BMC women's health · 2026Article
- A hierarchical dual-lock mechanism empowered epifluidic patch for rapid glucose feedback in exercise-induced sweating.Mikrochimica acta · 2026Article
- A hypothetical circadian‒endocrine pathway linking melanopsin-expressing ipRGC dysfunction in autoimmune retinopathy to sexual dysfunction.International ophthalmology · 2026Review
- Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice.Endocrine connections · 2026Article
- Retinal ganglion cell degeneration in glaucoma disrupts HPA axis temporal organization and dampens corticosterone production.Journal of neuroendocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Circadian clocks are internal timekeepers enabling organisms to adapt to recurrent events in their environment - such as the succession of day and night-by controlling essential behaviors such as food intake or the sleep-wake cycle. A ubiquitous cellular clock network regulates numerous physiological processes including the endocrine system. Levels of several hormones such as melatonin, cortisol, sex hormones, thyroid stimulating hormone as well as a number of metabolic factors vary across the day, and some of them, in turn, can feedback on circadian clock rhythms. In this review, we dissect the principal ways by which hormones can regulate circadian rhythms in target tissues - as phasic drivers of physiological rhythms, as zeitgebers resetting tissue clock phase, or as tuners, affecting downstream rhythms in a more tonic fashion without affecting the core clock. These data emphasize the intricate interaction of the endocrine system and circadian rhythms and offer inroads into tissue-specific manipulation of circadian organization.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.