ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Cannabinoid efficacy for pain: dose, chronicity and route.Frontiers in neuroscience · 2026Review
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7 authors.
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Abstract
The promiscuous ligand cannabidiol (CBD) shows promise as an analgesic, but its complex pharmacodynamics make it difficult to identify its mechanism(s) of action. Putative CBD receptors including cannabinoid receptors CB1 and CB2, as well as Trpv1 and Trpa1-the receptors for capsaicin and mustard oil (AITC), respectively-have been proposed to contribute to CBD-mediated analgesia. Larval zebrafish have several attributes that lend themselves to inquiries into the biology of nociception. The neural circuits underlying nociception in zebrafish larvae are highly analogous to those found in higher vertebrates. Notably, the small size and optical clarity of zebrafish enable holistic evaluation of analgesic function utilizing behavioral and imaging platforms. We report that in larval zebrafish of either sex, CBD serves both anti- and pronociceptive functions. Utilizing place aversion assays as a proxy for nociception, we found that low concentrations of CBD inhibit aversion to noxious chemical stimuli including AITC and acetic acid. Counterintuitively, we found that higher concentrations of CBD potentiated nocifensive behavior as measured by enhanced thermal aversion and increased locomotion. Knockout of Trpa1b eliminated the algogenic effects of CBD while having no effect on its analgesic properties, as it abolished
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.