Evidence map›Paper›PMID 41775621›Full record

ArticleBMJ open diabetes research & care2026

Association of weekday sleep duration and estimated glucose disposal rate: the role of weekend catch-up sleep.

Zhanhong Fan, Ruotong Wei, Tian Chen, Xingyue Yan, Shijia Yin, Yanfei Cao, Lydia Idowu Akinyemi, Jie Zhong, Hui Shi, Feng Zhang

Abstract read
In one paragraph

Article in BMJ open diabetes research & care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhanhong FanSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Ruotong WeiSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Tian ChenSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Xingyue YanSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Shijia YinSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Yanfei CaoSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Lydia Idowu AkinyemiSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China.
Jie ZhongSchool of Nursing, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China.
Hui ShiSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China shihui1@shchest.org zhangfeng820909@163.com.
Feng ZhangSchool of Nursing and Rehabilitation, Nantong University, Nantong, People's Republic of China shihui1@shchest.org zhangfeng820909@163.com.ORCID http://orcid.org/0000-0003-4798-5145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExisting studies have demonstrated a close association between sleep duration and insulin resistance (IR), diabetes, and related metabolic disorders. The estimated glucose disposal rate (eGDR) serves as a reliable marker of IR. This study examined the association between weekday sleep duration and eGDR, and the moderating role of weekend catch-up sleep (WCS).

methodsWe analyzed data from the National Health and Nutrition Examination Survey (2009-2023) using a cross-sectional study design to examine the association between weekday sleep duration and eGDR, while further investigating the moderating role of WCS on this relationship. Restricted cubic splines (RCS) were employed to assess potential nonlinear associations between sleep duration and eGDR, with piecewise regression analyses conducted based on identified inflection points to evaluate threshold effects. Generalized linear models and multivariable regression models were used to analyze the associations between different weekday sleep duration categories, WCS, and eGDR.

resultsThis analysis included 23 475 participants. RCS modeling revealed an inverted U-shaped relationship between sleep duration and eGDR, with an inflection point at 7.32 hours. Below this threshold, increased sleep improved eGDR (β=0.273, 95% CI 0.224 to 0.322, p<0.001), while exceeding it was inversely associated (β=-0.222, 95% CI -0.272 to -0.171, p<0.001). Multivariable regression showed that, for those with <7.32 hours of weekday sleep, 1-2 hours of WCS was associated with increased eGDR (β=0.296, 95% CI 0.107 to 0.484, p=0.002) compared with no WCS. The >2 hours WCS group negatively moderated the relationship between weekday sleep and eGDR (β=-0.568, 95% CI -0.970 to -0.167, p=0.005).

conclusionThis study revealed a significant inverted U-shaped relationship between weekday sleep duration and eGDR, identifying an optimal duration of approximately 7.32 hours, and that WCS is beneficial only in moderation and specifically for those with weekday sleep debt, whereas it may be detrimental for those who already sleep sufficiently. These findings underscore the importance of personalized sleep recommendations.

Indexed as

Blood GlucoseInsulin ResistanceSleep DurationAdultBiomarkersCross-Sectional StudiesFemaleHumansLinear ModelsMaleMiddle AgedNutrition SurveysRegression AnalysisTime FactorsUnited StatesYoung AdultBiomarkersBlood GlucoseGlucose Metabolism DisordersInsulin ResistancePopulation HealthSleep

Identifiers

PMID41775621
PMCPMC12958941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.