Evidence map›Paper›PMID 41775529›Full record

ArticleJournal of clinical pathology2026

Microglandular adenosis, triple negative breast carcinoma and DNA repair defects.

Mariel Bedell, Edaise M da Silva, Pier Selenica, Andrea M Gazzo, Juan Blanco Heredia, Thais Basili, Esther Elishaev, Lakshmi Harinath, Emilia Diego, Nishant Tageja and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mariel Bedell *Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Edaise M da Silva *Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-3281-7333
Pier SelenicaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Andrea M GazzoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Juan Blanco HerediaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0001-9526-7450
Thais BasiliDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Esther ElishaevDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Lakshmi HarinathDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Emilia DiegoDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Nishant TagejaDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jorge S Reis-FilhoMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Rohit BhargavaDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA bharrx@upmc.edu.ORCID http://orcid.org/0000-0002-1225-8418

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Sarat Chandarlapaty, Simon N. Powell · 2020 to 2026
$16.3M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA247749
6 · The paper itself

Abstract

aimsA subset of microglandular adenosis (MGA) displays protein expression and molecular genetic alterations similar to those of synchronous triple-negative breast carcinoma (TNBC), supporting the hypothesis that MGA is a non-obligate precursor lesion to a subset of breast carcinomas. Here, we further explore this association in the context of genomic instability.

methodsWe use whole-genome sequencing to investigate the genetic landscape of two unusual cases of MGA associated with carcinoma in the setting of two distinct varieties of genomic instability.

resultsThe first case describes a patient with Lynch Syndrome developing a low-grade TNBC of the left breast with adenoid cystic-like and MGA-like growth patterns and a contralateral, right breast MGA. Both carcinoma and contralateral MGA showed loss of MSH2 and MSH6 proteins. Molecular studies identified somatic

conclusionsGenomic instability, either due to mismatch repair protein deficiency or due to HRD, may play a role in MGA, MGA-associated carcinogenesis and distinct morphological patterns.

Indexed as

Biomarkers, TumorDNA RepairFibrocystic Breast DiseaseTriple Negative Breast NeoplasmsDNA-Binding ProteinsFemaleGenomic InstabilityHumansLoss of HeterozygosityMiddle AgedMutS Homolog 2 ProteinWhole Genome SequencingBiomarkers, TumorDNA-Binding ProteinsG-T mismatch-binding proteinMSH2 protein, humanMutS Homolog 2 ProteinBreast NeoplasmsCARCINOMAIMMUNOHISTOCHEMISTRYPathology, Molecular

Identifiers

PMID41775529
PMCPMC13078391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.