Evidence map›Paper›PMID 41775463›Full record

ArticleBMJ open ophthalmology2026

Consensus on evidence gaps and unmet needs in childhood myopia: findings from a European Delphi study with eye care professionals and payers.

Wolf Lagreze, Paolo Nucci, Matthijs Versteegh, Caroline Klaver, Jesús Barrio-Barrio, Annegret Dahlmann-Noor, Rosario Gomez de Liaño, Neema Ghorbani-Mojarrad, Line Kessel, Jan Roelof Polling and 16 more

Abstract readConsensus Statement
In one paragraph

Article in BMJ open ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Wolf LagrezeDepartment of Neuro & Paediatric Ophthalmology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Paolo NucciDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milano, Italy.ORCID http://orcid.org/0000-0002-4036-703X
Matthijs VersteeghHuygens & Versteegh, Zwijndrecht, The Netherlands.
Caroline KlaverDepartment of Ophthalmology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Jesús Barrio-BarrioDepartment of Ophthalmology, Navarra Institute for Health Research (IdiSNA), Clínica Universidad de Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-0654-0249
Annegret Dahlmann-NoorPaediatric Ophthalmology, NIHR Moorfields Biomedical Research Centre, London, UK.ORCID http://orcid.org/0000-0002-7402-4350
Rosario Gomez de LiañoHospital Clinico San Carlos, Complutense University of Madrid, Madrid, Spain.
Neema Ghorbani-MojarradSchool of Optometry and Vision Science, University of Bradford, Bradford, UK.ORCID http://orcid.org/0000-0001-9171-3070
Line KesselDepartment of Ophthalmology, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9375-1510
Jan Roelof PollingDepartment of Ophthalmology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Arnaud SauerDepartment of Ophthalmology, Strasbourg University Hospitals, Strasbourg, France.
Alexander K SchusterDepartment of Ophthalmology, Mainz University, Mainz, Germany.ORCID http://orcid.org/0000-0002-6304-3599
Massimiliano SerafinoDepartment of Ophthalmology, IRCCS Istituto G. Gaslini, Children's Hospital, Genova, Italy.ORCID http://orcid.org/0000-0002-3906-1885
Edoardo VillaniDipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy.
Focke ZiemssenUniversity Eye Hospital, University of Leipzig, Leipzig, Germany.
Yvonne-Beatrice BoehlerFaculty of Applied Natural Sciences, TH Köln University of Applied Sciences, Leverkusen, Germany.
Stefano CapriSchool of Economics and Management, Cattaneo-LIUC University, Castellanza, Italy.
Fabrizio GianfrateHealth Economics and Outcome Research, University of Rome, Rome, Italy.
Joan-Antoni Valles CallolCatalan Institute of Health, Barcelona, Spain.
Olivier WongMédiQualité Omega, Paris, France.
Ting-Yen ChenIQVIA Ltd, London, UK.ORCID http://orcid.org/0009-0000-1974-6441
Christina LymperopoulouIQVIA Ltd, Athens, Greece.
Ioanna PalakaIQVIA Ltd, Athens, Greece.
Yogesh PunekarIQVIA Ltd, London, UK.
Dorothea von BredowIQVIA Commercial GmbH and Co OHG, Munich, Germany.
Kun Shi-van WielinkSanten SA, Amsterdam, The Netherlands kun.shivanwielink@santen.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsChildhood myopia is a growing global concern, associated with significant burdens. This study aimed to identify evidence gaps and unmet needs in childhood myopia management through a European Delphi panel involving eye care professionals (ECPs) with expertise in childhood myopia management and payers (ie, individuals with experience in health technology assessment, healthcare funding, drug pricing and/or reimbursement decisions).

methodsA modified Delphi method was employed, involving two rounds of online questionnaires followed by a final virtual workshop. The panel included 12 ECPs and 13 payers from seven European countries. Consensus was defined as ≥70% agreement among panellists.

resultsConsensus was achieved on all 37 statements across six categories: disease background, clinical burden, psychosocial/humanistic burden, economic burden, treatment options and unmet needs. Key findings included recognition of ethnicity and age as crucial factors in evaluating childhood myopia, as well as the minimal clinically important difference for progression reduction. The panel emphasised the need for long-term studies on the efficacy and safety of myopia treatments, especially their impact on reducing future complications. The impact of high myopia on quality of life and economic burden was also highlighted. Regarding unmet needs, despite some known factors, the exact mechanisms behind myopia development remain unclear. There is a need for comprehensive epidemiological data on European childhood myopia and regulatory-approved pharmacological treatments in Europe.

conclusionsConsensus was reached among European ECPs and payers on the evidence gaps and unmet needs in childhood myopia management. These findings can guide future research to establish the best strategies for childhood myopia management and mitigate the burden.

Indexed as

Health Services Needs and DemandMyopiaChildDelphi TechniqueEuropeEvidence GapsFemaleHumansMaleQuality of LifeSurveys and QuestionnairesChild health (paediatrics)Public healthVision

Identifiers

PMID41775463
PMCPMC12959050

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.