ArticleInvestigative and clinical urology2026
Reassessing age limits: Outcomes of radical nephroureterectomy in octogenarian patients with upper tract urothelial carcinoma.
Article in Investigative and clinical urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo assess whether radical nephroureterectomy (RNU) confers oncologic and perioperative benefit in patients aged 80 years or older with upper tract urothelial carcinoma (UTUC). MATERIALS AND
methodsThis retrospective cohort study included 710 patients who underwent RNU at a tertiary center from 2003 to 2022. Patients were stratified into octogenarian (OG) (≥80 years, n=96) and non-octogenarian (NOG) (<80 years, n=614) groups. Demographics, perioperative variables, and oncologic outcomes were compared. Multivariate Cox regression was performed for overall survival and cancer-specific survival (CSS).
resultsOG had a higher rate of hypertension (72.9% vs. 50.2%) and lower body mass index (23.6 kg/m² vs. 24.5 kg/m², p=0.028), with similar pathologic stage and tumor grade compared to NOG. OG were more likely to undergo minimally invasive surgery (84.3% vs. 75.3%, p<0.001). Overall complication rate was higher in OG (68.8% vs. 55.2%, p=0.013), but major complications were not (5.2% vs. 3.3%, p=0.340). At median follow-up of 43.6 months, no difference in CSS was found. Positive surgical margin was the only independent predictor of CSS.
conclusionsRNU can be safely and effectively performed in well-selected OG with UTUC. Age ≥80 years was not associated with inferior CSS outcomes or increased major morbidity.
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