Evidence map›Paper›PMID 41775220›Full record

ArticleRedox biology2026

Mitochondrial permeability transition pore desensitization by a novel dispiranic derivative prevents cardiac reperfusion injury.

Giampaolo Morciano, Gaia Pedriali, Giulia Turrin, Cristina Algieri, Esther Densu Agyapong, Debora La Mantia, Chiara Bernardini, Giorgia Canini, Anna Fantinati, Elena Nicoletta Colarusso and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giampaolo MorcianoMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Italy. Electronic address: giampaolo.morciano@uniba.it.
Gaia PedrialiMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
Giulia TurrinDepartment of Environmental and Prevention Sciences, University of Ferrara, Italy.
Cristina AlgieriDepartment of Medical Veterinary Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Esther Densu AgyapongMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
Debora La MantiaDepartment of Medical Veterinary Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Chiara BernardiniDepartment of Medical Veterinary Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Giorgia CaniniDepartment of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Università Cattolica del Sacro Cuore, Roma, Italy.
Anna FantinatiDepartment of Environmental and Prevention Sciences, University of Ferrara, Italy.
Elena Nicoletta ColarussoMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
Fabio MollicaMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
Daniela RamacciniMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
Alessandra PagliaraniDepartment of Medical Veterinary Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Carlotta GiorgiDepartment of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
Elena TremoliMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
Alessandro ArcovitoDepartment of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Università Cattolica del Sacro Cuore, Roma, Italy.
Salvatore NesciDepartment of Medical Veterinary Sciences, University of Bologna, Ozzano dell'Emilia, Italy.
Claudio TrapellaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address: claudio.trapella@unife.it.
Paolo PintonMaria Cecilia Hospital, GVM Care & Research, Cotignola, Italy; Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address: paolo.pinton@unife.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial permeability transition pore (PTP) opening is a major determinant of cardiac ischemia/reperfusion (I/R) injury, contributing to cardiomyocyte death and impaired cardiac function following revascularization. Despite extensive research, effective pharmacological strategies targeting PTP remain limited. Here, we report the identification and characterization of a novel class of dispiranic small molecules designed to inhibit PTP opening by targeting the c subunit of F

Indexed as

Mitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryAnimalsHumansMitochondriaMitochondria, HeartMitochondrial Proton-Translocating ATPasesMolecular Docking SimulationMolecular Dynamics SimulationMyocytes, CardiacRatsReactive Oxygen SpeciesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesReactive Oxygen Species

Identifiers

PMID41775220
PMCPMC12968426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.