ArticleOrganic letters2026
Zinc-Mediated Four-Component Carbonylation toward Direct Synthesis of α-Amino Ketones.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
α-Amino ketone plays an important role in medicinal chemistry due to its excellent multiple reaction sites, which serve as a chemical hub for constructing complex molecules. Moreover, its skeleton is also found in many bioactive molecules. The traditional methods for synthesizing α-amino ketones are usually limited by harsh reaction conditions and the use of presynthesized and toxic reagents. As a readily available synthetic reagent, organic iodides play an important role in organic synthesis due to their high reactivity and high functional group compatibility. Herein, we report a zinc-mediated carbonylation reaction involving alkyl iodides, aldehydes, and amines, which efficiently synthesized a series of α-amino ketone compounds.
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