ArticleProceedings of the National Academy of Sciences of the United States of America2026
METTL3-mediated N6-methyladenosine modification of
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Myocardial infarction (MI) affects millions of individuals worldwide, with ferroptosis recognized as a pivotal regulated cell death pathway in this context. N6-methyladenosine (m6A), the most prevalent mRNA modification, is essential in modulating RNA splicing, export, stability, and translation during MI progression. Nonetheless, the involvement of m6A modification in cardiomyocyte ferroptosis has yet to be elucidated. This study aimed to elucidate the regulatory mechanisms of m6A modification in cardiomyocyte ferroptosis by conducting an integrated analysis of methylated RNA immunoprecipitation-sequencing and RNA-sequencing data obtained from myocardial tissues of MI mice, to identify promising therapeutic strategies for MI. We demonstrated that the differentially m6A-modified DnaJ heat shock protein family member B1 (
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