Evidence map›Paper›PMID 41774798›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Global analysis of protein degradation reveals instability of diverse regulators in

Elliot J MacKrell, Brett Lomenick, Yanping Qiu, Hannah Jeckel, Jeff Jones, Tsui-Fen Chou, David A Tirrell

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Global analysis of protein degradation reveals instability of diverse regulators inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elliot J MacKrellDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0009-0006-5619-8548
Brett LomenickProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-5023-9998
Yanping QiuProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125.
Hannah JeckelDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Jeff JonesProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-7142-2222
Tsui-Fen ChouProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-2410-2186
David A TirrellDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-3175-4596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulated protein degradation underlies the timely execution of essential gene expression programs in bacteria. Here, we deployed time-resolved chemoproteomics, text mining of the PubMed and EcoCyc knowledge bases, and machine learning classification to identify proteolytic regulation in exponential and stationary phase

Indexed as

Escherichia coliEscherichia coli ProteinsProteolysisBacterial ProteinsBiofilmsEndopeptidase ClpGene Expression Regulation, BacterialMachine LearningProtease LaProtein StabilityProteomicsBacterial ProteinsEndopeptidase ClpEscherichia coli ProteinsProtease LaBONCATEscherichia colimachine learningprotein degradationproteomics

Identifiers

PMID41774798
PMCPMC12974527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.