Evidence map›Paper›PMID 41774789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.

Jigen Koike, Ken Nakae, Riichiro Hira, Yuichiro Yada, Honda Naoki

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jigen KoikeLaboratory of Data-driven Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashihiroshima 739-8526, Japan.ORCID 0009-0008-6756-4886
Ken NakaeDigital Twin Lab, Graduate School of Engineering, University of Fukui, Fukui 910-8507, Japan.ORCID 0000-0003-4183-1532
Riichiro HiraDepartment of Physiology and Cell Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo 113-8519, Japan.
Yuichiro YadaLaboratory of Data-driven Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0003-2277-9951
Honda NaokiLaboratory of Data-driven Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashihiroshima 739-8526, Japan.

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJFS2129MEXT | Japan Science and Technology Agency (JST) JPMJSP2132MEXT | Japan Society for the Promotion of Science (JSPS) JP22H05163MEXT | JST | Moonshot Research and Development Program (Moonshot) JPMJMS2024-9MEXT | NINS | Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences (ExCELLS) 19-102
6 · The paper itself

Abstract

Understanding how brain-wide neural circuits are genetically wired remains a fundamental question in neuroscience. While Sperry's chemoaffinity theory [Sperry,

Indexed as

BrainConnectomeAnimalsAxonsMiceSpatial TranscriptomicsTranscriptomecanonical correlation analysis (CCA)chemoaffinity theoryconnectomeneural wiringtranscriptome

Identifiers

PMID41774789
PMCPMC12974521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.