Evidence map›Paper›PMID 41774729›Full record

ArticleACS sensors2026

An Ultraresponsive Green Biosensor for Robust in Vivo Imaging of Synaptic Zinc Dynamics.

Hao Zhang, Manoj Kumar, Raquel Correia, Shengjie Yang, Wenyuan Huang, Carina Soares-Cunha, Patrick Andrew Cody, Yiyu Zhang, Xiaodong Tian, Shengyu Zhao and 4 more

Abstract read
In one paragraph

Article in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Hao ZhangDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Manoj KumarDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Raquel CorreiaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.
Shengjie YangDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.ORCID 0009-0004-2380-0622
Wenyuan HuangCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Carina Soares-CunhaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.
Patrick Andrew CodyDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Yiyu ZhangCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-8636-2827
Xiaodong TianCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-9590-9943
Shengyu ZhaoDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Mikhail DrobizhevDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, Montana 59717-384, United States.
Ana João RodriguesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0003-1968-7968
Thanos TzounopoulosDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Hui-Wang AiDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0002-5664-3270

Funding

Next-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3M
Synaptic, Cellular and Circuit Mechanisms of Cortical Plasticity after Cochlear DamageR01DC019618 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2021 to 2025
$3.1M
Cortical neuromodulatory mechanisms underlying adaptation and plasticityR01DC020923 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thanos Tzounopoulos · 2023 to 2026
$2.3M
Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium IndicatorsR01EB035430 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2024 to 2026
$1.4M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseR01AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2025 to 2026
$1.0M
NIA NIH HHS R01 AG077773NIBIB NIH HHS R01 EB033172NIBIB NIH HHS R01 EB035430NIDCD NIH HHS R01 DC019618NIDCD NIH HHS R01 DC020923
6 · The paper itself

Abstract

Despite its crucial role in neurotransmission and neural processing, direct in vivo measurement of Zn

Indexed as

Biosensing TechniquesGreen Fluorescent ProteinsSynapsesZincAnimalsFluorescent Chemosensor CompoundsHEK293 CellsHumansMiceFluorescent Chemosensor CompoundsGreen Fluorescent ProteinsZincgenetically encoded fluorescent biosensorin vivo neuroimagingneuromodulationprotein engineeringsynaptic zinc dynamics

Identifiers

PMID41774729
PMCPMC13181829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.