Observational studyRevista medica del Instituto Mexicano del Seguro Social2026
[Correlation of occlusion pressure with sedation in non-neurocritical patients].
Observational study in Revista medica del Instituto Mexicano del Seguro Social, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: Mechanical ventilation is used in conjunction with sedation, which is titrated with clinical scales based on the therapeutic objective. It is difficult to find a reliable marker of respiratory drive in critically ill patients, so determining the correlation between the depth of sedation and airway occlusion pressure at 100 milliseconds (P0.1) would help titrate the depth of sedation and regulate respiratory drive. Objective: To determine whether P0.1 correlates with the depth of sedation measured with a clinical RASS scale and the bispectral index. Material and methods: A prospective cohort study was conducted with non-neurocritical patients undergoing mechanical ventilation from April 1, 2023, to September 30, 2023, in a tertiary care hospital in Mexico City. Results: 229 patients were included. Pearson's correlation was applied comparing the simultaneously measured BIS with the P0.1, finding a correlation of 0.64 with a p < 0.001. The correlation of this with RASS was 0.43, with propofol -0.18, with benzodiazepines -0.036, with buprenorphine -0.25, and with dexmedetomidine 0.051. Conclusion: There was a stronger correlation of P0.1 with the BIS compared with the RASS and the doses of the drugs used. It could be used for titrating sedation in non-neurocritical patients.
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