Evidence map›Paper›PMID 41774485›Full record

Trial reportMedicine and science in sports and exercise2026

Effectiveness of a Remote Physical Activity Intervention in Individuals with Alzheimer's Disease and their Caregivers: Results from a Randomized Trial.

Lauren T Ptomey, Brian C Helsel, Robert N Montgomery, Richard A Washburn, Joseph R Sherman, Amanda N Szabo-Reed, Eric D Vidoni, Anna M Gorczyca, Amy Bodde, Julianne G Clina and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Medicine and science in sports and exercise, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren T PtomeyDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Brian C HelselDepartment of Neurology, The University of Kansas Medical Center, Kansas City, KS.
Robert N MontgomeryDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS.
Richard A WashburnDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Joseph R ShermanDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Amanda N Szabo-ReedDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Eric D VidoniDepartment of Neurology, The University of Kansas Medical Center, Kansas City, KS.
Anna M GorczycaDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Amy BoddeDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Julianne G ClinaDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.
Kristine N WilliamsSchool of Nursing, The University of Kansas Medical Center, Kansas City, KS.
Joseph E DonnellyDepartment of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS.

Funding

University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mohammad Haeri · 2021 to 2026
$25.3M
longitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Paige C Geiger · 2022 to 2026
$14.9M
A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer's Disease and their CaregiversR01AG061187 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI DONNELLY, JOSEPH E., PTOMEY, LAUREN TAYLOR · 2019 to 2023
$3.6M
Assessment of Physical Activity for Alzheimer's Disease Research in Down SyndromeK01AG083130 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Brian Helsel · 2023 to 2026
$501k
Body composition, physical activity, and cognitive function in Down syndromeF32AG094116 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Julianne Clina · 2025 to 2026
$157k
NIA NIH HHS F32 AG094116NIA NIH HHS K01 AG083130NIA NIH HHS P30 AG072973NIA NIH HHS R01 AG061187NIGMS NIH HHS P20 GM144269
6 · The paper itself

Abstract

purposeIndividuals with Alzheimer's disease and related dementias (ADRD) and their caregivers often experience reduced physical activity (PA), diminished functional fitness, and heightened health risks. Remotely delivered PA interventions may offer scalable and accessible solutions. This study compared a 6-month, group-based dyadic PA program delivered via real-time group videoconferencing (RGV) with an enhanced usual care (EUC) condition on changes in moderate-to-vigorous physical activity (MVPA) and functional fitness among dyads consisting of individuals with ADRD and their caregivers.

methodsDyads were randomized to either the RGV or EUC arm. Both arms received wearable activity trackers and twice-monthly individualized support. The RGV group additionally participated in live, thrice-weekly group exercise sessions via videoconference. Outcomes included accelerometer-assessed MVPA and standardized measures of functional fitness.

resultsNinety-nine dyads enrolled, with 90% retention at 6 months. Mean session attendance in the RGV arm was 74% for individuals with ADRD and 69.5% for caregivers. Neither group significantly increased daily MVPA, and there were no significant between-group differences in changes in daily MVPA or sedentary time (all P > 0.05). However, significant within-group improvements occurred in upper-body strength (arm curls) and aerobic capacity (2-minute step test) for both individuals with ADRD and caregivers (all P < 0.05). Compared with EUC, the RGV group showed greater improvements in aerobic capacity among individuals with ADRD (β = 8.97, P = 0.04) and in both arm curls (β = 1.67, P = 0.02) and aerobic capacity (β = 11.3, P < 0.001) among caregivers.

conclusionsAlthough MVPA did not increase in the RGV arm, both individuals with ADRD and caregivers demonstrated clinically meaningful gains in functional fitness, supporting the feasibility and benefit of remote dyadic PA programs.

Indexed as

Alzheimer DiseaseCaregiversExerciseExercise TherapyVideoconferencingAccelerometryAgedAged, 80 and overFemaleFitness TrackersHumansMaleMiddle AgedPhysical FitnessDEMENTIAEXERCISEFITNESSREMOTE DELIVERY

Identifiers

PMID41774485
PMCPMC13330425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.