Evidence map›Paper›PMID 41774404›Full record

ArticleDrug delivery and translational research2026

A multi-compartment pulsatile drug delivery system for sequential release: in vitro and in vivo evaluation.

Seung-Dong Yoo, Yejin An, Gayoung Kim, Beom Soo Shin, Soyoung Shin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seung-Dong YooSchool of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi, 16419, Korea.
Yejin AnSchool of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi, 16419, Korea.
Gayoung KimCollege of Pharmacy, Wonkwang University, 460 Iksandae-Ro, Iksan, Jeonbuk, 54538, Korea.
Beom Soo ShinSchool of Pharmacy, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi, 16419, Korea. bsshin@skku.edu.
Soyoung ShinCollege of Pharmacy, Chung-Ang University, 84 Heukseok-Ro, Dongjak-Gu, Seoul, 06974, Korea. shins@cau.ac.kr.ORCID http://orcid.org/0000-0001-8328-1087

Funding

Chung-Ang University 2024National Research Foundation of Korea NRF-2023R1A2C1007013
6 · The paper itself

Abstract

This study presents an innovative, structurally engineered, pulsatile oral drug delivery platform that enables programmable, sequential drug release by integrating a structurally engineered three-dimensional (3D)-printed capsular device with conventional immediate-release (IR) tablets. Unlike coating-based or multilayer systems, which suffer from complex manufacturing and inconsistent release profiles, the multi-compartment capsule provides precise and reproducible control over the release timing through simple structural modifications. Each compartment accommodated intact IR tablets, allowing immediate release from the open-window sections and delayed release from the barrier-enclosed compartments. The lag time (T

Indexed as

Drug Delivery SystemsEsomeprazoleNaproxenAdministration, OralAnimalsCapsulesDelayed-Action PreparationsDogsDrug LiberationMalePrinting, Three-DimensionalSolubilityTabletsCapsulesDelayed-Action PreparationsEsomeprazoleNaproxenTablets3D printingDelayed releaseDrug delivery systemPharmacokineticsPulsatile release

Identifiers

PMID41774404
PMCPMC13619672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.