Evidence map›Paper›PMID 41774403›Full record

ArticleBreast cancer (Tokyo, Japan)2026

Three cases of whole breast irradiation for breast cancer in patients with Lymphangioleiomyomatosis (LAM).

Rumiko Kinoshita, Mitsuchika Hosoda, Fumi Kato, Hirokazu Kimura, Kaoruko Shimizu, Takashi Mori, Kentaro Nishioka, Takayuki Hashimoto, Masato Takahashi, Satoshi Konno and 1 more

Abstract readCase Reports
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In one paragraph

Article in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rumiko KinoshitaDepartment of Radiation Oncology, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, Hokkaido, 060-8638, Japan. rumiko0220@pop.med.hokudai.ac.jp.ORCID http://orcid.org/0000-0003-0803-4371
Mitsuchika HosodaDepartment of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan.
Fumi KatoDepartment of Radiology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Hirokazu KimuraDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Kaoruko ShimizuDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Takashi MoriDepartment of Radiation Oncology, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.
Kentaro NishiokaGlobal Center for Biomedical Science and Engineering, Hokkaido University, Sapporo, Japan.
Takayuki HashimotoGlobal Center for Biomedical Science and Engineering, Hokkaido University, Sapporo, Japan.
Masato TakahashiDepartment of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan.
Satoshi KonnoDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Hidefumi AoyamaDepartment of Radiation Oncology, Hokkaido University Hospital, N14W5 Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM) is a rare, low-grade metastatic disease characterized by cystic lung destruction. The existence of increased breast cancer risk among LAM patients, together with the proposed role of estrogen in the onset and progression of LAM, suggests a potential shared pathophysiological mechanism between LAM and breast cancer. We experienced three cases of early-stage breast cancer with LAM. All three cases were treated with breast-conserving surgery followed by radiation therapy and hormone therapy. There were no serious adverse events associated with the radiotherapy, and the patients have progressed without recurrence or metastasis of breast cancer or worsening of LAM in any of the values measured during the follow-up period.

Indexed as

Breast NeoplasmsLymphangioleiomyomatosisAdultFemaleHumansMastectomy, SegmentalMiddle AgedBreast cancerLymphangioleiomyomatosis (LAM)Whole breast radiotherapy

Identifiers

PMID41774403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.