ArticleDigestive diseases and sciences2026
Phenotypic Analysis of Mice with Conditional Knockout of PPP2CA in Colonic Tissues.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the function and role of PPP2CA in the colon by analyzing the phenotype of colon-specific PPP2CA-knockout mice. PPP2CA is the gene encoding the catalytic subunit of serine/threonine protein phosphatases 2A (PP2A).
methodsA conditional knockout mouse model was established using the Cre/loxP system. Physiological changes in mice were recorded after tamoxifen-induced knockout. Phenotypic differences between wild-type mice and conditional knockout mice were observed through anatomical, molecular biological, label-free quantitative proteomic, and histological methods.
resultsThere were no significant differences in body weight and defecation between the knockout mice and wild-type mice. However, at the pathological level, the knockout group exhibited a higher abundance of goblet cells and increased proliferation of intestinal villus cells. Proteomic analysis indicated alterations in the expression of key proteins involved in processes such as metabolic reprogramming and immune response.
conclusionThe deletion of PPP2CA in the colon did not cause intestinal dysfunction; instead, it may enhance intestinal barrier function by promoting the proliferation of cells related to the mucosal barrier.
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