ArticleIntensive care medicine experimental2026
Ventilation-perfusion effects of negative-pressure ventilation: insights from an experimental rat model.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundMechanical ventilation typically utilizes positive-pressure ventilation (PPV), which fundamentally differs from physiological pressure conditions. In contrast, negative-pressure ventilation (NPV) more closely mimics physiological pressure conditions; however, its impact on ventilation-perfusion matching remains unclear. Therefore, we compared PPV and NPV in terms of their effects on ventilation-perfusion matching and determined the consequences of increasing end-expiratory pressure (EEP).
methodsAnesthetized rats (n = 9) were ventilated using PPV at a positive EEP of 0, 3, 6, and 9 cmH
resultsHigher PaO
conclusionsThe results indicate that compared with PPV, NPV enhances gas exchange and ventilation-perfusion matching in healthy lungs. Although NPV causes fewer ventilation-perfusion inequalities and reduced dead space ventilation, its efficacy may be limited by increased intrapulmonary shunting during excessive negative end-expiratory pressure levels. These results provide mechanistic support for the physiological benefits of subatmospheric ventilation and may provide a basis for further studies on the refinement of noninvasive and lung-protective ventilation strategies in clinical settings with impaired ventilation-perfusion matching, such as acute respiratory failure, postoperative care, and ventilator weaning.
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