ReviewNano convergence2026
Beyond persistence: SERS-driven strategies for PFAS detection and monitoring.
Review in Nano convergence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Next-Generation SERS Probes: Engineering Hotspots, Intelligent Molecular Targeting, and AI-Driven Spectral Analysis for Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
abstarctThis review explores surface-enhanced Raman spectroscopy (SERS)-driven strategies for the detection and monitoring of per- and polyfluoroalkyl substances (PFAS), a class of nearly 15,000 synthetic compounds known for their exceptional chemical stability and environmental persistence. Due to the high bond dissociation energy of carbon-fluorine bonds, PFAS accumulate globally in water and soil, posing severe risks to human health, including cancer, liver toxicity, and immune suppression. As regulatory bodies like the U.S. EPA establish stringent maximum contaminant levels as low as 4 ng/L (ppt level), there is an urgent demand for rapid, cost-effective, and portable sensing platforms to complement traditional, high-cost analytical techniques like LC-MS/MS. SERS is highlighted as a powerful analytical tool capable of providing ultra-sensitive "molecular fingerprinting" by amplifying Raman signals through localized surface plasmon resonance (LSPR) on metallic nanostructures. This paper categorizes the fundamental mechanisms of SERS-based PFAS detection into three primary interaction strategies: (1) host-guest inclusion using molecular cavities like β-cyclodextrin or MOFs, (2) covalent bonding between PFAS functional groups and substrate surfaces, and (3) physical adsorption driven by hydrophobic and electrostatic forces. Despite its potential, practical SERS deployment faces challenges such as weak PFAS-surface affinity and spectral interference from complex environmental matrices. To address these, the review discusses emerging advancements, including fluorophilic surface functionalization, deep learning-based spectral deconvolution, and the integration of microfluidic platforms for real-time monitoring. Ultimately, these SERS-driven innovations provide a critical pathway toward achieving on-site, high-throughput quantification of trace PFAS in diverse water resources.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.