ArticleMolecular biology reports2026
β-glucuronidase: potential target for postmenopausal gut dysbiosis in Estrogen deficient chronic unpredictable mild stressed rats.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Pathogenic mechanisms and comprehensive therapeutic strategies of ovarian aging: targeting gut microbiota.Frontiers in microbiology · 2026Review
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7 authors.
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Abstract
backgroundEstrobolome is the subset of gut bacteria that produces β-glucuronidase enzyme, which helps maintain estrogen levels via facilitating enterohepatic recirculation of estrogen in the gut. Microbial β-glucuronidase enzyme facilitates the gut and associated brain and metabolic health in females. Estrogen shortage after menopause causes postmenopausal metabolic deficits, which may be due to alteration of β-glucuronidase levels. However, the effect of estrogen shortage on β-glucuronidase levels has not been elucidated yet. Thus, our study aimed to study the effect of estrogen shortage and chronic stress on β-glucuronidase levels during the postmenopausal state.
methodsFemale Sprague Dawley rats were bilaterally ovariectomized and exposed to chronic stress (CUMS) regularly for a total of 28 days to exacerbate postmenopausal complications. Basic physiology, such as uterine weight, serum estradiol levels, estrogen receptors (ER-α & ER-β) gene expression in proximal colon, and fecal gut estrobolome & β-glucuronidase enzyme levels (colon & fecal) were assessed. These parameters were further correlated with GUSB gene expression.
resultsEstrogen shortage and estrogen shortage stressed conditions indicate worsening uterine health, as indicated by a substantial reduction in uterine tissue weight, systemic estradiol concentration, and decreased expression of estrogen receptors (ER-α & ER-β genes) in the colon. With this, estrogen shortage, chronic stress, and their combination showed damage in gut health as shown by substantial alteration in gut estrobolome, reduction in microbial β-glucuronidase enzyme activity, and downregulation of GUSB gene expression.
conclusionThus, estrogen shortage and chronic stress together reduce microbial β-glucuronidase enzyme levels and downregulate GUSB gene expression.
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