SynthesisMolecular biology reports2026
The role of extracellular vesicles in endometriosis: A systematic review of pathogenesis, diagnostic biomarkers, and therapeutic potential.
Synthesis in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundExtracellular vesicles (EVs), including exosomes, play pivotal roles in the pathogenesis, diagnosis, and treatment of endometriosis. These nanosized vesicles carry bioactive molecules such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), proteins, and lipids, facilitating intercellular communication and modulating the mechanisms that drive disease progression. This systematic review aims to synthesize the current evidence on the role of EVs in the pathophysiology of endometriosis, their potential as diagnostic biomarkers, and their therapeutic applications.
methodsA comprehensive systematic review was conducted following the PRISMA guidelines. A systematic search of PubMed, Web of Science, Embase, and Scopus was performed for studies published between 2019 and 2024. The search terms included “extracellular vesicles” AND “endometriosis”, “pathogenesis” AND “diagnostic biomarkers” AND “therapeutic potential” AND “targeted therapy”. After screening 327 records, 269 unique studies were assessed. Following a full-text review of the remaining articles, 43 studies were included in the qualitative synthesis.
resultsOur review identified critical roles of EVs in immune modulation, epithelial-mesenchymal transition (EMT), and fertility impairment, all of which contribute to the progression of endometriosis. EVs carry molecular cargo that mirrors disease pathophysiology, highlighting their potential as noninvasive biomarkers for early diagnosis and disease monitoring. Additionally, engineered EVs offer novel therapeutic strategies for targeting disease-specific pathways.
conclusionsThis review highlights the multifaceted roles of EVs in endometriosis. EV-derived biomarkers, particularly miRNAs and proteins, show promise for noninvasive diagnosis and disease monitoring, while engineered EVs hold potential for targeted therapeutic interventions. These findings highlight the transformative potential of EVs in the diagnosis, prognosis, and treatment of endometriosis.
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Registered trials
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