ArticlePediatric radiology2026
Diffusion-weighted imaging of the spinal cord in children after prenatal myelomeningocele repair.
Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLittle is known about the impact of spinal cord microstructural alterations after prenatal myelomeningocele (MMC) repair and their associations with neurological clinical assessments.
objectiveTo assess spinal cord diffusivity using diffusion-weighted imaging (DWI) obtained between 10 months and 30 months of age in children who underwent prenatal MMC repair, and to explore associations with neurological clinical assessments. MATERIALS AND
methodsThis retrospective cohort study included children who underwent prenatal MMC repair from November 2011 to May 2023. All children met the Management Of Myelomeningocele Study (MOMS) inclusion criteria. DWI (b=0 s/mm
resultsThirty-six children were included (23 fetoscopic, 13 open-hysterotomy repairs). ADC values were significantly higher in children with intact S1 motor function (1.25 [1.00-1.89] vs 1.19 [1.00-1.30]×10
conclusionLower ADC values at the lesion level were associated with worse neurological and urological clinical assessments in children after prenatal MMC repair, suggesting that DWI may provide imaging biomarkers of spinal cord integrity.
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