Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Sravya Kurapati *Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5240-642X
Changsik Shin *Department of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0009-0004-3783-5340
Krisztina Szabo *Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8461-9294
Yu LiuDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0007-6599-5685
Azree Z AshrafDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0001-5306-1582
Balazs KoscsoDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-9676-2066
Chinmayee DashThe Morningside Graduate School of Biomedical Sciences at the UMass Chan Medical School , Worcester, MA, USA.ORCID 0000-0002-2677-603X
Katherine L KruckowDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-2730-8163
Leonardo E NavarroDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0008-3916-7226
Amanda M ClarkDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.ORCID 0009-0004-9487-9972
Monalee SahaCenter for Neurogastroenterology, Johns Hopkins University School of Medicine , Baltimore, MA, USA.ORCID 0009-0009-5508-8576
Sushma NagarajCenter for Neurogastroenterology, Johns Hopkins University School of Medicine , Baltimore, MA, USA.ORCID 0000-0001-5166-1309
Wenhui WangDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0000-3777-8316
Jun ZhuDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0834-8178
Kevin BrownDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.ORCID 0000-0003-2959-2401
Travis ThomsonDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-8994-8241
Natalia ShulzhenkoCollege of Veterinary Medicine, Oregon State University , Corvallis, OR, USA.ORCID 0000-0003-0077-8456
Andrey MorgunDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-8924-6108
Christina E BaerDepartment of Microbiology, Sanderson Center for Optical Experimentation (SCOPE), University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-8909-2583
Shanthi SrinivasanDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-6275-2369
Subhash KulkarniCenter for Neurogastroenterology, Johns Hopkins University School of Medicine , Baltimore, MA, USA.ORCID 0000-0002-2298-0623
Pankaj J PasrichaCenter for Neurogastroenterology, Johns Hopkins University School of Medicine , Baltimore, MA, USA.ORCID 0000-0002-8727-683X
Lauren A PetersDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3747-0474
Milena BogunovicDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0247-626X
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Mechanism of Enteric NeuropathyR01DK080684 · NIDDK · EMORY UNIVERSITY · PI Shanthi K Srinivasan · 2009 to 2026
$6.1M
Mucosal Macrophages and Tertiary Lymphoid Structures in IBDR01DK107603 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGUNOVIC, MILENA · 2016 to 2025
$4.0M
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous SystemR01AG066768 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOFF, LOYAL ANDREW, KULKARNI, SUBHASH · 2021 to 2025
$3.3M
The role of a novel viral-like signalling pathway in synaptic plasticity and neurological disordersR01NS112492 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THOMSON, TRAVIS · 2019 to 2023
$1.8M
Developing a Microphysiological System of a Humanized Gut-Brain-Axis for Ageassociated Transmissible NeuropathologiesR21AG072107 · NIA · JOHNS HOPKINS UNIVERSITY · PI KOPPES, ABIGAIL NELSON, KULKARNI, SUBHASH · 2022 to 2023
$484k
Microbiota, Tertiary Lymphoid Structures and Chronic Inflammation in the Human GutR21AI157369 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGUNOVIC, MILENA, MORGUN, ANDRIY · 2021 to 2022
$451k
Integration of Enteric Immune and Nervous Systems in the Mucosal Recall Immune ResponseR21AI126351 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BOGUNOVIC, MILENA · 2016 to 2017
$408k
Harvard Digestive Disease CenterIcahn School of Medicine at Mount SinaiKenneth Rainin FoundationLeona M. and Harry B. Helmsley Charitable TrustNational Institute of Allergy and Infectious Diseases R21AI126351-01NCATS NIH HHS UL1 TR004419NCATS NIH HHS UL1TR004419NIAID NIH HHS R21 AI126351NIAID NIH HHS R21 AI157369NIA NIH HHS R01 AG066768NIA NIH HHS R01AG066768NIA NIH HHS R21 AG072107NIA NIH HHS R21AG072107NIDDK NIH HHS R01 DK080684NIDDK NIH HHS R01DK080684NIDDK NIH HHS R01 DK107603NIDDK NIH HHS R01DK107603NIH HHSNINDS NIH HHS R01 NS112492NINDS NIH HHS R01NS112492Penn State College of MedicinePennsylvania Department of Health
6 · The paper itself
Abstract
Proper organization of the enteric nervous system (ENS) is critical for normal gastrointestinal (GI) physiology. Inflammatory bowel disease (IBD) disrupts key GI functions, including bowel motility. However, in many IBD patients, motility disorders persist even during remission, suggesting an irreversible ENS defect secondary to IBD. Here, we show that postinflammatory GI motility dysfunction arises from structural remodeling of the ENS, driven by a combination of neuronal loss and neurogenesis. During mucosal inflammation, enteric neurons upregulate CCL2 expression, facilitating the recruitment of monocytes into the myenteric plexus within the intestinal muscle. Monocyte-derived macrophages infiltrate the myenteric ganglia, contributing to excessive ENS remodeling and postinflammatory motility dysfunction. This neuroimmune axis is counterbalanced by a hypoxia-induced stress response in enteric neurons mediated by HIF1α. Enhancing the neuron-intrinsic hypoxia pathway limits ENS remodeling and preserves motility. In summary, this study presents a mechanistic model of postinflammatory GI motility dysfunction and proposes a therapeutic strategy to maintain ENS integrity and function during inflammation.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment. · full record | OpenQuestion