Evidence map›Paper›PMID 41774045›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2026

Effects of HIV and Adverse Childhood Experiences on Neurocognition.

Elizabeth M Inman, Candice W Ramsammy, Alisa Kalegina, Reuben N Robbins, Avy Violari, Rachel Kidman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth M InmanProgram in Public Health, Stony Brook University (State University of New York), Stony Brook, NY.ORCID 0000-0002-0679-138
Candice W RamsammyPerinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa.
Alisa KaleginaSchool of Social Welfare, Stony Brook University (State University of New York), Stony Brook, NY.
Reuben N RobbinsHIV Center for Clinical and Behavioral Science, New York State Psychiatric Institute and Columbia University, New York, NY; and.
Avy ViolariPerinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa.
Rachel KidmanProgram in Public Health, Stony Brook University (State University of New York), Stony Brook, NY.

Funding

Violence and onward HIV transmission in perinatally-infected adolescentsR01MH119878 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIDMAN, RACHEL, VIOLARI, AVY · 2019 to 2023
$2.8M
NIMH NIH HHS R01 MH119878NIMH NIH HHS R01MH119878
6 · The paper itself

Abstract

backgroundBoth HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an interaction between the 2 and downstream effects on neurocognition. The purpose of this study was to test the effects of PHIV, childhood adversity, and their interaction on neurocognition in a sample of South African adolescent boys.

settingSoweto, South Africa.

methodsAdolescent boys aged 15-19 years enrolled in a longitudinal study between November 2020 and June 2023. Recruitment was stratified by HIV status. At baseline, participants completed the ACE measure. Six months later they completed a battery of neurocognitive assessments ( NeuroScreen ). We created several regression models to examine the effects of HIV status, ACEs, and their interaction on neurocognition. We also built several exploratory models to probe the effects of viral suppression and various kinds of ACEs.

resultsParticipants living with PHIV scored significantly lower than those without HIV on several neurocognitive domains. Among those living with PHIV, participants with a detectable viral load during the study exhibited significantly lower performance on several domains than those who were consistently virally suppressed. We found no support for the effect of ACEs or a significant HIV*ACEs interaction on neurocognition.

conclusionsOur results underscore the importance of medication adherence and viral suppression among youth living with HIV.

Indexed as

Adverse Childhood ExperiencesCognitionHIV InfectionsAdolescentHumansLongitudinal StudiesMaleNeuropsychological TestsSouth AfricaViral LoadYoung Adultadolescenceadverse childhood experiencesneurocognitive disordersperinatal HIVSouth Africa

Identifiers

PMID41774045
PMCPMC13100952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.