ArticleAsian journal of andrology2026
Human pyriform sperm heads in infertile men and assisted reproductive technology outcomes: a retrospective cohort study based on propensity score matching.
Article in Asian journal of andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explores the effect of pyriform sperm heads on basic semen parameters, advanced sperm functions, and assisted reproductive technology outcomes. From 2300 patients with pyriform sperm heads in semen, a cohort of 59 couples from the Andrology Clinic of West China Second University Hospital (Sichuan University, Chengdu, China) between January 2022 and July 2024 undergoing assisted reproductive technology were studied. After 108 cycles with 81 embryos transferred, 37 couples achieved clinical pregnancy. Sperm concentration, percentage vitality, total motility, normal morphology, nuclear maturity, acrosomal integrity, acrosome reaction, and mitochondrial membrane potential were significantly lower in the pyriform sperm head group than those in the control group by propensity score matching (all P < 0.05). Non-progressive motility, immotile spermatozoa, the teratozoospermia, sperm deformity, DNA fragmentation index, and DNA stainability were higher in the pyriform sperm head group than those in the control group after propensity score matching (all P < 0.05). Nine morphometric parameters from 2805 typical pyriform sperm heads were evaluated. Cut-off values for predictive diagnostic use of 24.0%, 31.6%, 29.8%, 16.1%, 17.3%, 22.1%, and 9.2% were proposed for the proportion of pyriform sperm heads in seminal samples with abnormal DNA fragmentation index, high DNA stainability, sperm nuclear maturity, sperm acrosome integrity, acrosome reaction, acrosin activity, and mitochondrial membrane potential, respectively. High-quality embryos (35.2% vs 16.8%), clinical pregnancy (46.2% vs 43.8%), and live birth rates (21.5% vs 18.8%) were higher of spermatozoa from samples with a low proportion of pyriform sperm heads (≤38.5%) than with a high proportion of pyriform spermatozoa (>38.5%). The percentage of pyriform sperm heads could be introduced as a diagnostic evaluation parameter before treatment of sperm function and assisted reproductive technology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.